Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury
Le Zhang, Lijuan Xu, Haihu Chen, Wannian Zhang, Chengguo Xing, Zhuo Qu, Jian‐Qiang Yu, Chunlin Zhuang
Topics & Concepts
ChemistrySulforaphaneKEAP1ThioetherIsothiocyanateSulfoneActivator (genetics)CytotoxicityBiochemistryInflammationPharmacologyStereochemistryIn vitroTranscription factorImmunologyBiologyPolymer chemistryGeneGenomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsSulfur Compounds in Biology