Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates
Xinyu Ling, Liying Chang, Heqi Chen, Xiaoqin Gao, Jianhang Yin, Yi Y. Zuo, Yujia Huang, Bo Zhang, Jiazhi Hu, Tao Liu
Topics & Concepts
Trans-activating crRNACRISPRGenome editingBiologyCas9Computational biologyNucleaseMultiplexGeneGeneticsCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesRNA regulation and disease