One year in review 2020: pathogenesis of rheumatoid arthritis
Daiana Giannini, M. Antonucci, Fiorella Petrelli, Silvia Bilia, Alessia Alunno, Ilaria Puxeddu
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both genetic, epigenetic and environmental factors. The discovery of new gene polymorphisms and their association with disease susceptibility have added new elements to better clarify RA pathogenesis. In the last year, important elements have been added to the current knowledge of mechanisms regulating innate and adaptive immunity in RA, leading to discovering new targets for the development of disease-modifying therapies. Thus, in this review we summarise the new insights resulting from a literature research data published in the last year.
Topics & Concepts
MedicineRheumatoid arthritisPathogenesisDiseaseImmunologyAutoimmune diseaseEpigeneticsArthritisEpigenesisGenetic predispositionBioinformaticsGeneGeneticsGene expressionInternal medicineDNA methylationBiologyRheumatoid Arthritis Research and TherapiesMonoclonal and Polyclonal Antibodies ResearchCytokine Signaling Pathways and Interactions