Increasing prevalence of hypervirulent ST5 methicillin susceptible <i>Staphylococcus aureus</i> subtype poses a serious clinical threat
Ying Jian, Lin Zhao, Na Zhao, Huiying Lv, Yao Liu, Lei He, Qian Liu, Min Li
Abstract
susceptibility tests. However, MSSA subtype isolates exhibited relatively high virulence upon the analysis of virulence factors. Furthermore, MSSA subtype isolates displayed higher hemolysis capacity and higher ability to adhere to epithelial cells including A549 human alveolar epithelial cells and HaCaT human skin keratinocytes, caused more severe infections in murine abscess model. With its high virulence and enhanced magnitude in the past decades, the ST5 MSSA subtype poses a serious clinical threat hence more attention should be paid to the prevention and control.
Topics & Concepts
Staphylococcus aureusVirulenceMicrobiologyBiologyPanton–Valentine leukocidinPathogenMethicillin-resistant Staphylococcus aureusVirologyGeneBacteriaGeneticsAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingBacterial Identification and Susceptibility Testing