Synthesis and evaluation of porphyrin glycoconjugates varying in linker length: preliminary effects on the photodynamic inactivation of<i>Mycobacterium smegmatis</i>
Charlie F. Dixon, Ana N. Nottingham, Ana Frances Lozano, J. Alexander Sizemore, Logan A. Russell, Chelsea Valiton, Kimberly L. Newell, Dominique Babin, William C. Bridges, Matthew R. Parris, David V. Shchirov, Nicole L. Snyder, Joshua V. Ruppel
Abstract
were used to determine the effects of the linker in photodynamic inactivation (PDI) studies. Preliminary results demonstrated an increase in photodynamic inactivation with a decrease in linker length. Investigations are underway to determine the mechanism for these results.
Topics & Concepts
Mycobacterium smegmatisPorphyrinGlycoconjugateLinkerChemistryCombinatorial chemistryPhotodynamic therapyPhotochemistryBiochemistryOrganic chemistryComputer scienceMycobacterium tuberculosisMedicineTuberculosisOperating systemPathologyPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine ChemistryNanoplatforms for cancer theranostics