Copper-Catalyzed C-3 Functionalization of Imidazo[1,2-<i>a</i>]pyridines with 3-Indoleacetic Acids
Yinrong Wu, Lu Li, Kangmei Wen, Jie Deng, Jiewen Chen, Jie Shi, Ting Kai Wu, Jianxin Pang, Xiaodong Tang
Abstract
A copper-catalyzed C-3 functionalization of imidazo[1,2-a]pyridines with 3-indoleacetic acids through an aerobic oxidative decarboxylative process has been developed. The protocol provided a series of 3-(1H-indol-3-ylmethyl)-imidazo[1,2-a]pyridines in moderate to good yields under simple reaction conditions. Importantly, some products exhibited potent antiproliferative activity in cancer cell lines.
Topics & Concepts
ChemistrySurface modificationCatalysisCopperCombinatorial chemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Characterization of PyrrolesCatalytic Cross-Coupling Reactions