Cytotoxic triterpenoid glycosides from leaves of <i>Cyclocarya paliurus</i>
Huihui Sun, Wenyan Lv, Jie Tan, Yu-Cheng Tang, Hui Zhu, Jian‐Bo Qu, Jing Li, Jian-Ping Wu, Xi-Wen Chang, Zhi‐Chun Yang, Wen‐Xuan Wang, Zu-Hui Chen, Kang Xu
Abstract
Three previously undescribed dammarane triterpenoid glycosides (1-3) along with five known analogues (4-8) were isolated from the leaves of Cyclocarya paliurus. Their structures and configurations were determined on the basis of comprehensive spectroscopic analyses, chemical hydrolysis and DFT GIAO 13C NMR calculation. All the isolates were evaluated cytotoxic activities against seven human cancer cell lines (MCF-7, PC-3, Du145, NCI-H1975, PC-9, SKVO3 and HepG2). Moreover, compound 4 showed a wide spectrum of cytotoxicity against human cancer cells with IC50 values ranging from 11.31 to 29.51 µM.