Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
Santosha A. Vardhana, Madeline A. Hwee, Mirela Berisa, Daniel K. Wells, Kathryn E. Yost, Bryan H. King, Melody Smith, Pamela S. Herrera, Howard Y. Chang, Ansuman T. Satpathy, Marcel R.M. van den Brink, Justin R. Cross, Craig B. Thompson
Topics & Concepts
Oxidative phosphorylationCell biologyBiologyT cellCell growthOxidative stressStem cellCytotoxic T cellProgenitor cellMitochondrionDownregulation and upregulationPhosphorylationStimulationImmunologyImmune systemBiochemistryIn vitroEndocrinologyGeneCAR-T cell therapy researchCancer, Hypoxia, and MetabolismImmune cells in cancer