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Threshold Modulative Artificial GABAergic Nociceptor

Geunyoung Kim, Younghyun Lee, Jae Bum Jeon, Woon Hyung Cheong, Woojoon Park, Hanchan Song, Kyung Min Kim

2023Advanced Materials29 citationsDOI

Abstract

Abstract Gamma‐aminobutyric acid (GABA) is a crucial inhibitory neurotransmitter of the central nervous system. It modifies the signal threshold of the nociceptor, allowing it to react to external stimuli in various circumstances. Thus, GABAergic behaviors are critical characteristics of adaptive behavior in life. Here, a threshold‐modulative artificial GABAergic nociceptor is reported for the first time at a Pt/Ti/Nb 2 O 5− x /Al 2 O 3− y /Pt/Ti (top to bottom) of the double charge trapping structure. The Al 2 O 3− y layer contains deep defect states that function similarly to the GABA neurotransmitter in modulating the signal threshold. Meanwhile, the Nb 2 O 5− x layer traps volatile charges and produces nociceptive behaviors. The combined dynamics of the two layers readily offer threshold‐modulative GABAergic nociceptive behaviors. Based on these GABAergic behaviors, a method of implementing hot‐ and cold‐sensitive thermoreceptors is demonstrated and shows its potential applications in advanced sensory devices.

Topics & Concepts

GABAergicNociceptorNeuroscienceNeurotransmitterNociceptionInhibitory postsynaptic potentialMaterials sciencegamma-Aminobutyric acidSensory systemBiophysicsBiologyCentral nervous systemBiochemistryReceptorAdvanced Memory and Neural ComputingConducting polymers and applicationsNeuroscience and Neuropharmacology Research
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