Facile, rapid and efficient isolation of circulating tumor cells using aptamer-targeted magnetic nanoparticles integrated with a microfluidic device
Abolghasem Abbasi Kajani, Laleh Rafiee, Mohamadmahdi Samandari, Masoud A. Mehrgardi, Bahare Zarrin, Shaghayegh Haghjooy Javanmard
Abstract
. The isolated CTCs were further characterized using immunofluorescence staining. The overall results indicated the high potential of the present method for the detection and capture of CTCs.
Topics & Concepts
AptamerMicrofluidicsIsolation (microbiology)Magnetic nanoparticlesNanotechnologyCirculating tumor cellNanoparticleChemistryMaterials scienceMolecular biologyBiologyCancerBioinformaticsGeneticsMetastasisMicrofluidic and Bio-sensing TechnologiesNanopore and Nanochannel Transport StudiesMicrofluidic and Capillary Electrophoresis Applications