Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow
Alexander V. Nyuchev, Ting Wan, Borja Cendón, Carlo Sambiagio, Job J. C. Struijs, Michelle Ho, Moisés Gulı́as, Ying Wang, Timothy Noël
Abstract
The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions.
Topics & Concepts
MicroreactorChemistryContinuous flowPhotocatalysisFlow chemistryYield (engineering)Continuous reactorResidence time (fluid dynamics)Process engineeringFlow (mathematics)Chemical engineeringCombinatorial chemistryNanotechnologyOrganic chemistryCatalysisBiochemical engineeringMechanicsThermodynamicsPhysicsMaterials scienceGeotechnical engineeringEngineeringFluorine in Organic ChemistryRadical Photochemical ReactionsInnovative Microfluidic and Catalytic Techniques Innovation