Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer
Goutam Chakraborty, Kasmira Gupta, Natasha Kyprianou
Abstract
Prostate cancer is a highly heterogeneous disease. Progression on androgen deprivation therapy (ADT) to castration-resistant (CRPC), or neuroendocrine prostate cancer (NEPC), is associated with poor patient survival. This comment highlights recent evidence on the epigenetic mechanisms underlying the emergence of lineage plasticity and neuroendocrine differentiation in treatment-resistant prostate tumors.
Topics & Concepts
Prostate cancerEpigeneticsNeuroendocrine differentiationProstateLineage (genetic)Androgen deprivation therapyDiseaseCancer researchCancerChromoplexyMedicineTumour heterogeneityOncologyBiologyInternal medicinePCA3GeneticsGeneProstate Cancer Treatment and ResearchEpigenetics and DNA MethylationCancer, Lipids, and Metabolism