Reduced mitochondrial respiration in T cells of patients with major depressive disorder
Stefanie Gamradt, Helge Hasselmann, Aline Taenzer, Jelena Brasanac, Victoria Stiglbauer, Arne Sattler, Max Sajitz-Hermstein, Sylwia Kierszniowska, Caren Ramien, Jan Nowacki, Lea Mascarell-Maricic, Katja Wingenfeld, Dominique Piber, Andreas Ströhle, Katja Kotsch, Friedemann Paul, Christian Otte, Stefan M. Gold
Abstract
) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology.