Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review
Sandra B. Amado-Garzón, Luisana Molina Pimienta, Andrea Vejarano-Pombo, Mariana Vélez-Bonilla, Jaime Moreno‐Chaparro, Adriana Buitrago-López
Abstract
Vitamin B12 (B12) is a molecule involved in several biological. Abnormally high levels are frequently found, but their causes can be multiple, and consequences have not been clearly elucidated. The objective of this review was to summarize the current evidence on the associations of elevated B12 and the development of cancer, and all-cause mortality in adults. Six references looking at mortality and seven looking at cancer risk were included. The evidence suggests an association between elevated B12 with a higher risk of cancer, with risk ratios ranging 1,88 to 5,9. There was less consistent evidence linking vitamin B12 and mortality.