Assessing the relationship between the cerebral metabolic rate of oxygen and the oxidation state of cytochrome-c-oxidase
Daniel Milej, Ajay Rajaram, Marianne Suwalski, Laura Morrison, Leena N. Shoemaker, Keith St. Lawrence
Abstract
Significance: Hyperspectral near-infrared spectroscopy (hsNIRS) combined with diffuse correlation spectroscopy (DCS) provides a noninvasive approach for monitoring cerebral blood flow (CBF), the cerebral metabolic rate of oxygen (CMRO 2 ) and the oxidation state of cytochromec-oxidase (oxCCO). CMRO 2 is calculated by combining tissue oxygen saturation (S t O 2 ) with CBF, whereas oxCCO can be measured directly by hsNIRS. Although both reflect oxygen metabolism, a direct comparison has yet to be studied.
Topics & Concepts
Cytochrome c oxidaseOxygenMetabolic rateCerebral blood flowIschemiaHemodynamicsChemistryBiologyInternal medicineBiochemistryMedicineEndocrinologyEnzymeOrganic chemistryOptical Imaging and Spectroscopy TechniquesNon-Invasive Vital Sign MonitoringHemodynamic Monitoring and Therapy