Decarboxylative 1,4-carbocyanation of 1,3-enynes to access tetra-substituted allenes <i>via</i> copper/photoredox dual catalysis
Ya Chen, Jun‐Jie Wang, Yixin Lü
Abstract
-hydroxyphthalimide esters are utilized as radical precursors, and the reported mild and redox-neutral protocol has broad substrate scope and remarkable functional group tolerance. This strategy allows for the synthesis of diverse multi-substituted allenes with high chemo- and regio-selectivities, also permitting late stage allenylation of natural products and drug molecules.
Topics & Concepts
ChemistryTetraCatalysisCombinatorial chemistryPhotoredox catalysisSubstrate (aquarium)CopperFunctional groupAlkylDual roleRadicalPrimary (astronomy)Dual (grammatical number)RedoxOrganic chemistryMedicinal chemistryPhotocatalysisAstronomyLiteratureArtPolymerPhysicsGeologyOceanographyRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods