Process optimization by response surface methodology for preparation and evaluation of methotrexate loaded chitosan nanoparticles
N. Raghavendra Naveen, Mallesh Kurakula, Buduru Gowthami
Topics & Concepts
ChitosanFactorial experimentResponse surface methodologyParticle sizeNanoparticleCmaxMethotrexateCentral composite designChemistryMaterials sciencePharmacokineticsPharmacologyChromatographyNuclear chemistryNanotechnologyMathematicsBiochemistryMedicineSurgeryStatisticsPhysical chemistryAdvanced Drug Delivery SystemsProtein purification and stabilityDrug Solubulity and Delivery Systems