The Interplay between Adeno-Associated Virus and Its Helper Viruses
Anita F. Meier, Cornel Fraefel, Michael Seyffert
Abstract
The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.
Topics & Concepts
Helper virusVirologyParvovirusHerpes simplex virusBiologyVirusAdeno-associated virusParvoviridaeViral replicationGeneticsGeneVector (molecular biology)Recombinant DNAVirus-based gene therapy researchHerpesvirus Infections and TreatmentsAnimal Virus Infections Studies