Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization
Fengshi Li, Zhihua Rong, Rui Zhang, Shuai Niu, Xiao Di, Leng Ni, Changwei Liu
Abstract
experiments were carried out in a carotid artery injury model and verified the above functions and the effect on inhibiting vascular restenosis. Immune regulation-based platelet membrane coated nanoparticle loaded with IL10 proved to be an excellent candidate for targeting vascular injury and holds promise as an innovative drug delivery system for suppressing vascular restenosis.
Topics & Concepts
RestenosisMacrophage polarizationInflammationInterleukin 10PlateletCancer researchVascular smooth muscleM2 MacrophageImmune systemMedicineMacrophageCell biologyMaterials scienceChemistryImmunologyInternal medicineBiologyStentSmooth muscleIn vitroBiochemistryExtracellular vesicles in diseaseImmune cells in cancerInflammatory Biomarkers in Disease Prognosis