Chemical constituents of <i>Trillium tschonoskii</i> Maxim.
Ting Yan, An‐Hua Wang, Gaosheng Hu, Jing‐Ming Jia
Abstract
A new fatty acid-spirostan steroid glycoside ester, a new cholestane glycoside and a new stilbene trimer, along with three known steroidal saponins, were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium tschonoskii Maxim. The structure of isolated compounds was elucidated by spectroscopic analysis. Compound 1–6 were assessed for their cytotoxicity against cancer cell lines (MCF-7, HCT-116, DU-145, SGC-7901, MCF-7/ADR, K562/ADR), and the result showed that compound 4 was highly toxic to six human tumor cell lines.
Topics & Concepts
RhizomeCholestaneChemistryCancer cell linesGlycosideLiliaceaeCytotoxicityStereochemistrySteroidTrimerMaximTraditional medicineBiochemistryBiologyBotanyCancer cellCancerOrganic chemistryMedicineDimerHormonePolitical scienceGeneticsLawIn vitroPhytochemical Studies and BioactivitiesGarlic and Onion StudiesNatural product bioactivities and synthesis