Transition‐Metal‐Catalyzed Regioselective Functionalization of Monophosphino‐<i>o‐</i>Carboranes
Ziyang Zhang, Xuepeng Zhang, Yuan Jia, Chang‐Duo Yue, Sixuan Meng, Jian Chen, Guang‐Ao Yu, Chi‐Ming Che
Abstract
Abstract A facile approach to the synthesis of diaryl‐ and dialkyl‐substituted monophosphino‐ o‐ carboranes by rhodium(I)‐catalyzed phosphine‐directed B 3,6 −H activation has been developed for the first time. Upon switching rhodium(I) to palladium(II), C ‐arylated and B 6 ‐halogenated products were obtained by using t BuOLi and Li 2 CO 3 as base, respectively. These discoveries provide some simple and efficient approaches to the modification of monophosphino‐ o‐ carboranes.
Topics & Concepts
RegioselectivityRhodiumSurface modificationCatalysisPhosphineTransition metalChemistryPalladiumCombinatorial chemistryPolymer chemistryOrganic chemistryPhysical chemistryBoron Compounds in ChemistryOrganoboron and organosilicon chemistryRadiopharmaceutical Chemistry and Applications