PVA Capped Mn-Doped ZnS Encapsulated Nontoxic MoS<sub>2</sub> Nano-Sheet Probe for the Sensitive Estimation of Cardiovascular <i>β</i>-Blocking Agent Acebutolol in Biomedical and Environmental Samples
Yuvarajgouda N. Patil, Manjunath B. Megalamani, Sharanappa T. Nandibewoor
Abstract
In the present study, a novel sensor PVA capped Mn doped ZnS incorporated MoS 2 nanosheet composite modified gold electrode (PVA-Mn:ZnS/MoS 2 @GE) has been developed for the determination of acebutolol (ACB). Cyclic voltammetry (CV) and square wave voltammetry (SWV) were used to measure the electrochemical performance of ACB. When nanocomposite PVA-Mn:ZnS/MoS 2 was used as a modifier in electrode-based sensors, results in well-resolved peaks and improved electrochemical current sensitivity compared to bare gold electrode. Using the SWV technique in pH 7.0 phosphate buffer, the examination of samples of biological, environmental and tablet spiked with ACB was monitored, the limit of detection and quantification is found to be 0.38 × 10 −9 M and 1.28 × 10 −9 M respectively. CV, energy dispersive X-ray, scanning electron microscopy, and impedance spectroscopy were performed to characterize the electrode material. A suitable mechanism was proposed for the number of protons and electrons involved in the redox reaction of ACB.