Spread of Klebsiella pneumoniae ST45 Producing GES-5 Carbapenemase or GES-1 Extended-Spectrum β-Lactamase in Newborns and Infants
Elżbieta Literacka, Radosław Izdebski, Paweł Urbanowicz, Dorota Żabicka, Joanna Klepacka, Iwona Sowa-Sierant, Iwona Żak, A. Garus-Jakubowska, Waleria Hryniewicz, Marek Gniadkowski
Abstract
GES-type extended-spectrum β-lactamases (ESBLs), such as GES-1, mutate by Gly170Asn/Ser substitutions into carbapenem-hydrolyzing variants, of which GES-5 is seen relatively more frequently (1, 2). In some countries GES-5-producing Enterobacterales have occurred repeatedly in clinical cases and/or outbreaks (1, 3–7) and in hospital or aquatic environmental samples (7–10). blaGES-Like genes reside mainly in class 1 integrons found on diverse plasmids or chromosomes in various species and clones (3, 4, 6–8, 10–12). We report a cluster of infant cases with carbapenem-nonsusceptible GES-positive Klebsiella pneumoniae isolates.