An intelligent <i>T</i><sub>1</sub>–<i>T</i><sub>2</sub> switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques
Chunshu Pan, Junjie Lin, Jianjun Zheng, Chuang LIU, Bo Yuan, Ozioma Udochukwu Akakuru, M. Zubair Iqbal, Qianlan Fang, Jiapeng Hu, Jia Chen, Jie Lin, Qi Dai, Xiuyu Guo, Zihou Li, Tao Zhang, Xu Chen, Xuehua Ma, Tianxiang Chen, Aiguo Wu, Yinhua Jin
Abstract
A <italic>T</italic><sub>1</sub>–<italic>T</italic><sub>2</sub> switchable MRI contrast agent, hyaluronic acid-modified iron oxide nanoparticle–polyacrylic acid, is used for the identification of vulnerable atherosclerotic plaques by macrophage phagocytosis. It could reveal promising enhancement in MRI.
Topics & Concepts
Contrast (vision)NanoparticlePolyacrylic acidHyaluronic acidMRI contrast agentMaterials scienceIdentification (biology)Nuclear magnetic resonanceBiomedical engineeringNanotechnologyMedicinePolymerBiologyAnatomyPhysicsComposite materialOpticsBotanyProteoglycans and glycosaminoglycans researchProtease and Inhibitor MechanismsCharacterization and Applications of Magnetic Nanoparticles