A comparative analysis of solvent cast <scp>3D</scp> printed carbonyl iron powder reinforced polycaprolactone polymeric stents for intravascular applications
Jasvinder Singh, Pulak M. Pandey, Tejinder Kaur, Neetu Singh
Abstract
In the present research, the effectiveness of developed methodology based on solvent cast 3D printing technique was investigated by printing the different geometries of the stents. The carbonyl iron powder (CIP) reinforced polycaprolactone (CIPC) was used to print three pre-existing stent designs such as ABBOTT BVS1.1, PALMAZ-SCHATZ, and ART18Z. The physicochemical behavior was analyzed by X-ray diffraction and scanning electron microscopy. The radial compression test, three-point bending test and stent deployment test were carried out to analyze the mechanical behavior. The degradation behavior of the stents was investigated in static as well as dynamic environment. To investigate the hemocompatible and cytocompatible behaviors of the stents, platelet adhesion test, hemolysis test, protein adsorption, in vitro cell viability test, and live/dead cell viability assay were performed. The results revealed that stents had the adequate mechanical properties to perform the necessary functions in the human coronary. The degradation studies showed slower degradation rate in the dynamic environment in comparison to static environment. in vitro biological analysis indicated that the stents represented excellent resistance to thrombosis, hemocompatible functions as well as cytocompatible nature. The results concluded that PALMAZ-SCHATZ stent represented better mechanical properties, cell viability, blood compatibility, and degradation behavior.