Engineered ionizable lipid nanoparticles mediated efficient siRNA delivery to macrophages for anti-inflammatory treatment of acute liver injury
Hongqian Zhang, Feng Ding, Zongwei Zhu, Qian Sun, Chuanxu Yang
Topics & Concepts
Gene silencingSmall interfering RNATransfectionIn vivoChemistryMacrophageRNA interferenceInflammationIn vitroDownregulation and upregulationInternalizationCell biologyImmunologyMedicineBiologyRNABiochemistryCellGeneBiotechnologyRNA Interference and Gene DeliveryImmunotherapy and Immune ResponsesPhagocytosis and Immune Regulation