Therapeutic silencing of lncRNA RMST alleviates cardiac fibrosis and improves heart function after myocardial infarction in mice and swine
Teng Ma, Fan Qiu, Yanshan Gong, Hao Cao, Gonghua Dai, Daohan Sun, Dongling Zhu, Han Lei, Zhongmin Liu, Ling Gao
Abstract
Our findings identified RMST as a crucial regulator of cardiac fibrosis, and targeting RMST may develop a novel and efficient therapeutic strategy for treating fibrosis-related cardiac diseases.
Topics & Concepts
Gene knockdownFibrosisGene silencingCardiac fibrosisMedicineCancer researchFibroblastBiologyPathologyApoptosisIn vitroBiochemistryGeneCancer-related molecular mechanisms researchCardiac Valve Diseases and TreatmentsCardiac Fibrosis and Remodeling