Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis
Jungwoo Wren Kim, Xiling Yin, Aanishaa Jhaldiyal, Mohammed Repon Khan, Ian Martin, Zhong Xie, Tamara Perez‐Rosello, Manoj Kumar, Leire Abalde-Atristain, Jinchong Xu, Li Chen, Stephen Eacker, D. James Surmeier, Nicholas T. Ingolia, Ted M. Dawson, Valina L. Dawson
Topics & Concepts
LRRK2BiologyDopaminergicNeurodegenerationCell biologyTranslational regulationTranslation (biology)Untranslated regionInduced pluripotent stem cellParkinson's diseaseNeuroscienceGeneticsMutationMessenger RNADopamineGeneInternal medicineDiseaseMedicineEmbryonic stem cellParkinson's Disease Mechanisms and TreatmentsCRISPR and Genetic EngineeringGenetic Neurodegenerative Diseases