Axisymmetric bis-tridentate Ir(<scp>iii</scp>) photoredox catalysts for anticancer phototherapy under hypoxia
Li Wei, Rajesh Kushwaha, Anyi Dao, Zhongxian Fan, Samya Banerjee, Huaiyi Huang
Abstract
A novel axisymmetric bis-tridentate Ir(III) photocatalyst (Ir3) with synergetic type I/II photosensitization and photocatalytic activity was reported. Ir3 exhibited high photocytotoxicity toward drug-resistant cancer cells under normoxia and hypoxia. The photoactivated anticancer mechanism of Ir3 were investigated in detail. Overall, this new photo-redox catalyst can overcome hypoxia and drug resistance-related problems in clinical anticancer therapy.
Topics & Concepts
ChemistryCatalysisHypoxia (environmental)PhotocatalysisRedoxCombinatorial chemistryDrugMedicinal chemistryCancer researchOxygenPharmacologyBiochemistryOrganic chemistryMedicineAdvanced Photocatalysis TechniquesNanoplatforms for cancer theranosticsAdvanced Nanomaterials in Catalysis