<i>N</i>‐Cyanation of Primary and Secondary Amines with Cyanobenzio‐doxolone (CBX) Reagent
Zimin Chen, Weiming Yuan
Abstract
An efficient electrophilic N-cyanation of amines with a stable and less-toxic cyanobenziodoxole reagent towards the synthesis of cyanamides is disclosed. This synthetically practicable strategy allows the construction of a wide variety of cyanamides under very mild and simple conditions with a broad functional group compatibility, and showcases a huge potential in late-stage modification of complex molecules.
Topics & Concepts
CyanationReagentElectrophileChemistryPrimary (astronomy)Combinatorial chemistryOrganic chemistryCatalysisPhysicsAstronomySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions