Highly bioactive novel aryl-, benzyl-, and piperazine-selenoureas: synthesis, structural characterization and in vitro biological evaluation
Ziad Moussa, Ranem Kaddoura, Haythem A. Saadeh, Nael Abutaha, Saleh A. Ahmed
Abstract
values of 1.8 μΜ and 1.2 μΜ observed against the challenging former triple-negative breast cancer cell line and the latter one, respectively. The chemical structures of all new compounds were fully characterized by multinuclear nuclear magnetic resonance (NMR) spectroscopy and high accuracy mass measurements.
Topics & Concepts
PiperazineArylCombinatorial chemistryBiological activityChemistrySolventCancer cell linesNuclear magnetic resonance spectroscopyIn vitroOrganic chemistryCancer cellBiochemistryBiologyCancerGeneticsAlkylOrganoselenium and organotellurium chemistrySulfur-Based Synthesis TechniquesCholinesterase and Neurodegenerative Diseases