Novel isoniazid-spirooxindole derivatives: design, synthesis, biological evaluation, in silico ADMET prediction and computational studies
Mayuri A. Borad, Divya J. Jethava, Manoj N. Bhoi, Chirag Patel, Himanshu A. Pandya, Hitesh D. Patel
Topics & Concepts
AntimycobacterialIsoniazidIn silicoChemistryMycobacterium tuberculosisDocking (animal)Combinatorial chemistrySmall moleculeRational designLigand efficiencyStereochemistryComputational biologyTuberculosisBiochemistryNanotechnologyLigand (biochemistry)PathologyBiologyMaterials scienceReceptorGeneMedicineNursingComputational Drug Discovery MethodsSynthesis and biological activityCancer therapeutics and mechanisms