A fast and direct iodide-catalyzed oxidative 2-selenylation of tryptophan
Yuting Gao, Shaodong Liu, Liang Cheng, Li Liu
Abstract
A metal-free 2-selenylation of tryptophan derivatives is reported, where the use of iodide as the catalyst and oxone as the oxidant is key to obtain high yields. Various functional groups within the di-seleny and the indole ring are tolerated, and no racemization is generally observed.
Topics & Concepts
IodideChemistryCatalysisOxidative phosphorylationTryptophanCombinatorial chemistryOrganic chemistryBiochemistryAmino acidSulfur-Based Synthesis TechniquesOrganoselenium and organotellurium chemistryCatalytic C–H Functionalization Methods