Neurochemical balance and inhibition at the subacute stage after stroke
John Cirillo, Ronan A. Mooney, Suzanne Ackerley, P. Alan Barber, Victor M. Borges, Andrew N. Clarkson, Christine Mangold, April Ren, Marie‐Claire Smith, Cathy M. Stinear, Winston D. Byblow
Abstract
Magnetic resonance spectroscopy indicated higher excitation-inhibition ratios within motor cortex during subacute recovery than age-similar healthy controls. Measures obtained from adaptive threshold hunting paired-pulse transcranial magnetic stimulation indicated greater tonic inhibition in patients compared with controls. Therapeutic approaches that aim to normalize motor cortex inhibition during the subacute stage of recovery should be explored.
Topics & Concepts
Transcranial magnetic stimulationNeurochemicalMotor cortexBalance (ability)NeuroscienceStimulationTonic (physiology)PsychologyStroke (engine)Primary motor cortexMedicinePhysicsThermodynamicsTranscranial Magnetic Stimulation StudiesStroke Rehabilitation and RecoveryMuscle activation and electromyography studies