A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer
Malene Blond Ipsen, Ea Marie Givskov Sørensen, Emil Aagaard Thomsen, Simone Weiss, Jakob Haldrup, Anders Dalby, Johan Palmfeldt, Peter Bross, Martin Rasmussen, Jacob Fredsøe, Søren Klingenberg, Mads Ryø Jochumsen, Kirsten Bouchelouche, Benedicte Parm Ulhøi, Michael Borre, Jacob Giehm Mikkelsen, Karina D. Sørensen
Topics & Concepts
OlaparibPARP1BiologyPARP inhibitorCRISPRCancer researchProstate cancerSynthetic lethalityDNA repairCancerGeneticsPoly ADP ribose polymeraseGenePolymerasePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisProstate Cancer Treatment and Research