Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562
Nehad M. El‐Dydamony, Rana M. Abdelnaby, Rasha Abdelhady, Omaima Ali, Mohamed I. Fahmy, Rasha R. Fakhr Eldeen, Amira A. Helwa
Abstract
has strong potential as a multi-acting inhibitor on PI3K/AKT axis targeting breast cancer and leukaemia.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BApoptosisChemistryCell cycle checkpointCell cyclePharmacologyCancer researchBiochemistryStereochemistryBiologyPI3K/AKT/mTOR signaling in cancerSynthesis and biological activityQuinazolinone synthesis and applications