Angelica sinensis polysaccharide (ASP) attenuates diosbulbin-B (DB)-induced hepatotoxicity through activating the MEK/ERK pathway
Chunfeng Li, Shumin Liu, Jian Zheng, Yingwei Xue
Abstract
study illustrated that ASP activated the MEK/ERK pathway mediated autophagy to suppress high-dose DB-induced hepatotoxicity.
Topics & Concepts
MAPK/ERK pathwayViability assayApoptosisMTT assayAutophagyChemistryFlow cytometryHepatocyteCell cycle checkpointCell growthPharmacologyCell cycleIn vitroMolecular biologyKinaseBiologyBiochemistryAutophagy in Disease and TherapyTraditional Chinese Medicine AnalysisSphingolipid Metabolism and Signaling