Th17 T Cells and Immature Dendritic Cells Are the Preferential Initial Targets after Rectal Challenge with a Simian Immunodeficiency Virus-Based Replication-Defective Dual-Reporter Vector
Danijela Maric, Wesley A. Grimm, N. Greco, Michael D. McRaven, Angela J. Fought, Ronald S. Veazey, Thomas J. Hope
Abstract
data have developed a framework for understanding HIV cell tropism, the initial target cells in the rectal mucosa have not been identified. In this study, we identify these early host cells by using an innovative rhesus macaque rectal challenge model and methodology, which we previously developed. Thus, by shedding light on these early HIV/SIV transmission events, this study provides a specific cellular target for future prevention strategies.
Topics & Concepts
BiologySimian immunodeficiency virusVirologyTropismViral replicationTissue tropismTransduction (biophysics)VirusCell biologyBiochemistryHIV Research and TreatmentImmunotherapy and Immune ResponsesCytomegalovirus and herpesvirus research