Oligothiophene-based photosensitizers with tunable push–pull architectures: design, synthesis and characterization
Soraia Flammini, Manuele Di Sante, Paolo Emidio Costantini, Edoardo Jun Mattioli, Alessia Marconi, Eleonora Turrini, Silvia La Rosa, Maria Montrone, Tainah Dorina Marforio, Michela Nigro, Nicol Spallacci, Alberto Zanelli, Mattia Zangoli, Alberto Danielli, Matteo Di Giosia, Francesca Di Maria, Matteo Calvaresi
Abstract
= 4.0 nM for the most efficient PS) than common photosensitizers. Real-time fluorescence imaging revealed rapid membrane blebbing when the cells treated with HSA-OT were exposed to light, indicative of necrotic-like immunogenic cell death. Taken together, our findings highlight the power of molecular engineering in optimizing photosensitizer performance and provide proof of concept for the potential of HSA-OT conjugates as a multifunctional theranostic platform for cancer.