Synthetic strategies towards benzothiazole-based compounds of therapeutic potency: experimental, investigational and approved drugs
Reham A. Mohamed‐Ezzat, Galal H. Elgemeie
Abstract
Benzothiazoles play significant roles in modern therapeutical chemistry owing to their significant effects and their integration into various pharmaceutical agents for treating critical diseases. Several approved, investigational, and experimental benzothiazole-based drugs have been accomplished. Novel strategies targeting therapeutical benzothiazoles and up-to-date synthetic strategies of anti-neurodegenerative, anti-inflammatory, antitumor, anti-microbial, and anti-viral benzothiazoles are well-recognized and reviewed. The biological investigations of the newly synthesized compounds are emphasized. This comprehensive review is considered as a valuable source in drug discovery and development.
Topics & Concepts
Drug discoveryPharmacologyDrugInvestigational DrugsChemistryMedicineCombinatorial chemistryDrug developmentComputational biologyNanotechnologyBiological drugsSynthesis and biological activitySynthesis of Tetrazole DerivativesQuinazolinone synthesis and applications