Interplay among Different Fosfomycin Resistance Mechanisms in Klebsiella pneumoniae
Miriam Ortiz-Padilla, Inés Portillo-Calderón, B. de Gregorio-Iaria, Jesús Blázquez, Jesús Rodríguez‐Baño, Álvaro Pascual, José Manuel Rodríguez-Martínez, Fernando Docobo-Pérez
Abstract
The objectives of this study were to characterize the role of the uhpT , glpT , and fosA genes in fosfomycin resistance in Klebsiella pneumoniae and evaluate the use of sodium phosphonoformate (PPF) in combination with fosfomycin. Seven clinical isolates of K. pneumoniae and the reference strain (ATCC 700721) were used, and their genomes were sequenced. Δ uhpT , Δ glpT , and Δ fosA mutants were constructed from two isolates and K. pneumoniae ATCC 700721.
Topics & Concepts
FosfomycinKlebsiella pneumoniaeMicrobiologyKlebsiella infectionsKlebsiellaEnterobacteriaceaeBiologyAntibiotic resistanceAntibioticsEscherichia coliGeneticsGeneAntibiotic Resistance in BacteriaEscherichia coli research studiesUrinary Tract Infections Management