EGFR-Targeted Nanobody Functionalized Polymeric Micelles Loaded with mTHPC for Selective Photodynamic Therapy
Yanna Liu, Luca Scrivano, Julia D. Peterson, Marcel H.A.M. Fens, Irati Beltrán Hernández, Bárbara Mesquita, Javier Sastre Toraño, Wim E. Hennink, Cornelus F. van Nostrum, Sabrina Oliveira
Abstract
micelles displayed prolonged blood circulation kinetics, compared to free mTHPC, independently of the presence of EGa1. Thus, these results make these micelles a promising nanomedicine formulation for selective therapy.
Topics & Concepts
MicellePhotosensitizerChemistryPhotodynamic therapyEthylene glycolEpidermal growth factor receptorBiophysicsPhotochemistryAqueous solutionOrganic chemistryBiochemistryReceptorBiologyNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesNanoparticle-Based Drug Delivery