Population Genomics of <i>emm4</i> Group A Streptococcus Reveals Progressive Replacement with a Hypervirulent Clone in North America
Sruti DebRoy, Misu A. Sanson, Brittany J. Shah, Shirjana Regmi, Luis Alberto Vega, Chioma Odo, Pranoti Sahasrabhojane, Allison McGeer, Gregory J. Tyrrell, Nahuel Fittipaldi, Samuel A. Shelburne, Anthony R. Flores
Abstract
GAS identified emergence of a hypervirulent GAS clade defined by variation in endogenous DNA content and lacking augmented toxin gene expression relative to replaced strains. These findings expand our understanding of the molecular mechanisms underlying bacterial clonal emergence.
Topics & Concepts
BiologyPopulationGeneclone (Java method)GenomeStreptococcusGeneticsStreptococcus pyogenesMolecular epidemiologyGenotypeBacteriaStaphylococcus aureusDemographySociologyStreptococcal Infections and TreatmentsNeonatal and Maternal InfectionsAntimicrobial Resistance in Staphylococcus