Iron‐Catalyzed and Air‐Mediated C(<i>sp</i><sup>3</sup>)−H Phosphorylation of 1,3‐Dicarbonyl Compounds Involving C−C Bond Cleavage
Yingcong Ou, Yuanting Huang, Yu Liu, Yanping Huo, Yang Gao, Xianwei Li, Qian Chen
Abstract
Abstract A C( sp 3 )−H phosphorylation has been achieved via the iron‐catalyzed cross‐coupling reactions between 1,3‐dicarbonyl compounds and P(O)−H compounds involving C−C bond cleavages with air as the oxidant. This transformation provides a straightforward way to construct C( sp 3 )−P bonds, leading to the formation of β‐ketophosphine oxides in up to 93% yield with good functional group tolerance. magnified image
Topics & Concepts
ChemistryCatalysisYield (engineering)Bond cleavageCleavage (geology)Medicinal chemistryFunctional groupPhosphorylationCoupling reactionStereochemistryOrganic chemistryBiochemistryPolymerGeotechnical engineeringEngineeringMetallurgyFracture (geology)Materials scienceCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions