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Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein and PGE2 levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kβ nexus

Humera Jahan, Nimra Naz Siddiqui, Shazia Iqbal, Fatima Z. Basha, Maria Aqeel Khan, Tooba Aslam, M. Iqbal Choudhary

2022Life Sciences17 citationsDOI

Topics & Concepts

ChemistryIndole testChalconeReactive oxygen speciesGlycationTHP1 cell lineIn vitroInflammationPharmacologyBiochemistryStereochemistryCell cultureImmunologyBiologyReceptorGeneticsAdvanced Glycation End Products researchClick Chemistry and ApplicationsPeptidase Inhibition and Analysis
Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein and PGE2 levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kβ nexus | Litcius