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Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors

Assaf Kacen, Aaron Javitt, Matthias P. Kramer, David Morgenstern, Tomer Tsaban, Merav D. Shmueli, Guo Ci Teo, Felipe da Veiga Leprevost, Eilon Barnea, Fengchao Yu, Arie Admon, Lea Eisenbach, Yardena Samuels, Ora Schueler‐Furman, Yishai Levin, Alexey I. Nesvizhskii, Yifat Merbl

2022Nature Biotechnology118 citationsDOIOpen Access PDF

Topics & Concepts

AntigenBiologyProteomeComputational biologyMajor histocompatibility complexAntigenicityHuman proteome projectImmunologyGeneticsProteomicsGenevaccines and immunoinformatics approachesPeptidase Inhibition and AnalysisImmunotherapy and Immune Responses
Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors | Litcius