Highly efficient, catalyst-free, one-pot sequential four-component synthesis of novel spiroindolinone-pyrazole scaffolds as anti-Alzheimer agents: <i>in silico</i> study and biological screening
Hormoz Pourtaher, Yasaman Mohammadi, Alireza Hasaninejad, Aida Iraji
Abstract
Alzheimer's disease is a neurodegenerative disorder that impacts memory, thinking, and behavior, and currently, there is no effective cure available for its treatment.
Topics & Concepts
PyrazoleIn silicoCombinatorial chemistryChemistryCytotoxicityDocking (animal)In vitroStereochemistryBiochemistryNursingGeneMedicineMulticomponent Synthesis of HeterocyclesSynthesis and biological activityClick Chemistry and Applications