Early return of reflected waves increases right ventricular wall stress in chronic thromboembolic pulmonary hypertension
Masafumi Fukumitsu, Berend E. Westerhof, Dieuwertje Ruigrok, Natalia J. Braams, Joanne A. Groeneveldt, Ahmed A. Bayoumy, J. Tim Marcus, Lilian J. Meijboom, Frances S. de Man, Nico Westerhof, Harm Jan Bogaard, Anton Vonk Noordegraaf
Abstract
In chronic thromboembolic pulmonary hypertension (CTEPH), proximal localization of vessel obstructions is associated with poor right ventricular (RV) function compared with distal localization, though pulmonary vascular resistance, vascular compliance, characteristic impedance, and the magnitude of wave reflection are similar. In proximal CTEPH, the RV is exposed to an earlier return of the reflected wave. Early wave reflection may increase RV wall stress and compromise RV function.
Topics & Concepts
Chronic thromboembolic pulmonary hypertensionCardiologyInternal medicinePulmonary hypertensionMedicineVentricular functionCompliance (psychology)Vascular resistanceReflection (computer programming)HemodynamicsProgramming languageSocial psychologyPsychologyComputer sciencePulmonary Hypertension Research and TreatmentsCardiovascular Issues in PregnancyCardiovascular Function and Risk Factors