Palladium-catalyzed selective defluorinative arylation for the efficient stereospecific synthesis of (<i>E</i>)-β-fluoroacrylamides
Shiyu He, Xiaowei Yan, Hai‐Yong Tu, Xing‐Guo Zhang
Abstract
A practical and efficient method for the synthesis of ( E )-β-fluoroacrylamides was developed by the selective defluorinative arylation of trifluoropropanamides with arylboronic acids.
Topics & Concepts
ChemistryStereospecificityPalladiumCatalysisCombinatorial chemistryOrganic chemistryFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsCyclopropane Reaction Mechanisms