The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum
Binbin Lu, Meng Liu, Liang Gu, Ying Li, Shijun Shen, Gangqiang Guo, Fei Wang, Xiaohui He, Yuemeng Zhao, Xiaomin Shang, Liping Wang, Guang Yang, Qianshu Zhu, Jun Cao, Cizhong Jiang, Richard Culleton, Gang Wei, Qingfeng Zhang
Abstract
Mechanistic investigation revealed that the specific interaction of HMGB1 and centromeres constructed the precisely organized nuclear architecture, which coordinated with local chromatin structure to control the singular expression of virulence genes. Hence, this protein appears to be a critical architectural regulator for the pathogenesis of malaria infection and may be a new target for the development of an intervention strategy against malaria.
Topics & Concepts
Plasmodium falciparumMalariaParasite hostingPlasmodium (life cycle)BiologyVirologyGenomeImmunologyGeneticsComputer scienceGeneWorld Wide WebMalaria Research and ControlInvertebrate Immune Response Mechanismsvaccines and immunoinformatics approaches